1 autologous lmp2 specific cytotoxic t lymphocytes ctl for the treatment of relapsed ebv positive hl
báo cáo khoa học: " FCR (Fludarabine, Cyclophosphamide, Rituximab) regimen followed by 90yttrium ibritumomab tiuxetan consolidation for the treatment of relapsed grades 1 and 2 follicular lymphoma: a report of 9 cases" pot
Ngày tải lên :
10/08/2014, 10:21
... with WHO performance status of to 2, had achieved at least PR at the completion of FCR; the last chemotherapy with or without rituximab was administered at least three months before start of ... the majority of patients during FCR treatment, and in all of them after 90 Y-RIT Despite the high incidence of grade or neutropenia there were no patients requiring hospitalization for infection ... consistent with that expected in patients with NHL who have had extensive previous chemotherapy and not appeared to be increased after 90 Y-RIT Cytogenetic testing before treatment with RIT may...
- 5
- 287
- 0
SURGICAL OPTIONS FOR THE TREATMENT OF HEART FAILURE - PART 1 potx
Ngày tải lên :
11/08/2014, 15:20
... desperate outlook for these patients In their study, these authors examined the survival of patients with cardiomyopathy according to etiology fhe pt)oresi outlook by far was for patients with coronarv' ... patients This represents yet another opportunity to prolong the lives and relieve the suffering of heart failure patients and leave the door open for ultimate cardiac replacement with either transplantation ... Despite the substantial dangers anticipated in the application of CABCi to patients with advanced left ventricular dysfunction, the potential for recovery of function via grai\ing continued to...
- 20
- 411
- 0
Esomeprazole for the treatment of GERD in infants ages 1–11 months
Ngày tải lên :
14/11/2016, 06:20
... parallel-group, treatmentwithdrawal study conducted in 33 centers in the United States, France, Germany, and Poland The study followed guidelines established by the FDA SELECT CRITERIA Infants ages to ... majority (83%) of patients showed improvement in GERD symptoms within weeks of starting openlabel esomeprazole therapy The downward trend in symptom severity was greatest in the vomiting/regurgitation, ... months: They had a clinical diagnosis of suspected GERD based on symptoms, endoscopically proven GERD, laboratory test results, diagnostic tests Patients were required to have at least of the...
- 16
- 359
- 0
Báo cáo khoa học: Oligomannose-coated liposomes efficiently induce human T-cell leukemia virus-1-specific cytotoxic T lymphocytes without adjuvant doc
Ngày tải lên :
14/03/2014, 23:20
... in postallogeneic stem cell transplantation patients The expression of Tax by the host cell targets them for attack by CTL, resulting in the elimination of the infected cell [32] However, the expression ... transplantation patients, which might account for the efficacy of this therapy [31] Therefore, the efficient induction of HTLV-1-specific CTL by OML ⁄ Tax could be adapted to prevent the relapse of ATL ... induction of HTLV-1-specific CTLs Therefore, OML ⁄ Tax could be adapted as a prophylactic for acute transformation of indolent ATL On the other hand, patients with acute- or lymphoma-type ATL are...
- 9
- 243
- 0
Báo cáo y học: "Control of mucosal virus infection by influenza nucleoprotein-specific CD8+ cytotoxic T lymphocytes" ppsx
Ngày tải lên :
12/08/2014, 15:20
... contribute to the control of influenza are directed toward the hemagglutinin and neuraminidase surface proteins [15] or the M2 protein [17] The objective of the present study was to define the ... infection of the mucosal surface of the respiratory tract; pneumonia can occur but this is uncommon [8] Thus, for CTLs to be of value for human influenza, they must mediate control of virus infection ... infection of respiratory tract epithelial cells In this regard, it has been suggested that CTLs in the circulation or submucosal sites cannot cross the basement membrane of the mucosal surface; this...
- 8
- 356
- 0
Báo cáo y học: " Human immunodeficiency virus type 1 specific cytotoxic T lymphocyte responses in Chinese infected with HIV-1 B''''/C Recombinant (CRF07_BC)" pdf
Ngày tải lên :
13/08/2014, 05:22
... proteins has led to the postulate that the frequency of CTL recognition is inversely correlated with the variability of the viral sequences[31,32] We have seen the similar clustering pattern of ... Vpu The immunodominant regions are widely distributed throughout the entire genome, with Gag, Pol and Nef being the most frequently targeted Compared to the dominant epitopes scattered within the ... anti-retroviral therapy naive at the time of study and infected with HIV-1 CRF07_BC The study was approved by the institutional review board of National Center for AIDS/STD Control and Prevention...
- 12
- 314
- 0
báo cáo hóa học:" Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs" pot
Ngày tải lên :
18/06/2014, 15:20
... data for all patients who underwent vaccination with hTERT-pulsed DCs homing of the tumour -specific T cell populations to tumour sites contributes to the effectiveness of the antitumour immunity ... in the study were promiscuous Ex Vivo Cytotoxicity of In Vivo Generated T Cells T2 -cytotoxicity Cumulative cytotoxicity results for all patient samples show that after two cycles of vaccination ... molecules These changes enhance the ability of DCs to present Ag to naïve T lymphocytes in secondary lymphoid compartments and, thereby, generate TAAg -specific cytotoxic T lymphocytes (CTLs) Activated...
- 23
- 439
- 0
Báo cáo y học: " Reduction of the HIV-1 reservoir in resting CD4+ T-lymphocytes by high dosage intravenous immunoglobulin treatment: a proof-of-concept study" pot
Ngày tải lên :
10/08/2014, 05:21
... in the study Written informed consent was obtained and the study was approved by the Research Ethics Committee at the University of Gothenburg and the Medical Products Agency of Sweden Patient ... between the HIV-1 RNA from plasma-activated T- cells and the SGS from the T- cell culture This correlation falls within the cluster of plasma sequences, implying that activation of the latent reservoir ... eradication of the virus in patients on ART The decay rate of the latent reservoir in such patients is extremely slow [2,12,13] and the substantial decrease of the reservoir found in five of the...
- 8
- 378
- 0
Báo cáo y học: "HIV-1 is budded from CD4+ T lymphocytes independently of exosomes" pot
Ngày tải lên :
12/08/2014, 01:21
... in the infectivity of these three virion preparations To this end, we infected Jurkat cells with each of the viruses of the same amount of RT activity and monitored virus infection and replication ... g for 90 to obtain the virion preparation (S) To compare virion compositions, a same volume of the cleared supernatant from the first centrifugation and the pass-through from Page of the filtration ... sedimentation followed by fractionation [31] Besides its requirement of the special agent iodixanol, the fractionation manipulation in this protocol is quite laborious The other protocol is to use...
- 5
- 203
- 0
Báo cáo y học: " Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients" potx
Ngày tải lên :
12/08/2014, 15:22
... reflect rather the level of systemic inflammation than the specific activation status of pathogenic immune cells Moreover, their use seems to be limited Bittner et al Arthritis Research & Therapy ... whether its validity is limited under these circumstances Therefore, in light of the current results further patient studies need to assess the prognostic value, time course and clinical validity ... months Note that the y-axis in D) is split for better clarity and that two patients are marked in red especially in the case of tocilizumab which inhibits the systemic acute phase reaction at...
- 9
- 344
- 0
Báo cáo y học: " A peptide-loaded dendritic cell based cytotoxic T-lymphocyte (CTL) vaccination strategy using peptides that span SIV Tat, Rev, and Env overlapping reading frames" ppt
Ngày tải lên :
13/08/2014, 09:21
... prevent the expression of the second coding exon of Tat Our interpretation of this scenario in the context of our operational definition of an "immutable CTL epitope" is that SIVtat2ex is a transitional ... virus of SIVtat1ex; and that in certain settings SIVtat1ex virus cannot durably transit to its more fit SIVtat2ex form because the host maintains a potent CTL selection targeted against an epitope ... Provocatively, after years of infection, this animal continued to maintain the low-fitness SIVtat1ex virus with no evidence for the ability of the more fit SIVtat2ex to emerge by correcting the stop codons...
- 13
- 147
- 0
Báo cáo y học: "Critical role of hnRNP A1 in HTLV-1 replication in human transformed T lymphocytes" pdf
Ngày tải lên :
13/08/2014, 13:20
... used: 5'gatccccAGCAAGAGATGGCTAGTGCttcaagagaGCACTAGCCATCTCTTGCTtttttgga aa-3', and 5'-gatccccCAGCTGAGGAAGCTCTTCAttcaagagaTGAAGAGCTTC CTCAGCTGtttttgga aa-3' The sequence of each oligonucleotide was ... 5'-AAGCAATTTTGGAGGTGGTG-3' and antisens, 5'-ATAGCCACCTTGGTTTCGTG-3', gag/polHTLV-1sense, 5'-CCCTCCAGTTACGATTTCCA-3' and antisens, 5'GGCTTGGGTTTGGATGAGTA-3', envHTLV-1sense, 5'CTGTGGTGCCTCCTGAACT-3' ... the mutation of a putative binding site of hnRNP A1 to the XRE leads to an increase of the post-transcriptional activity of Rex Next, to further address the effect that hnRNP A1 might exert on...
- 13
- 282
- 0
Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
Ngày tải lên :
18/06/2014, 16:20
... cell transplantation (HSCT) Studies in such patients indicate that Treg cells increase in response to the treatment, and that this effect seems to be increased with prolonged time of treatment [66] ... not accurately reflect the status and behavior of their counterparts localized in the target organ In this latter regard, there is experimental evidence that the blood carries at least a fraction ... not mimic, at least reflect events ongoing at the specific site of inflammation Whether or not those events that are translated into the blood encompass autoantigenspecific Treg cell defects...
- 12
- 573
- 0
Báo cáo y học: "Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factor" ppt
Ngày tải lên :
09/08/2014, 03:24
... lead to the recruitment of a cohort of transcription factors that cooperate to initiate MMP-1 and MMP-13 transcription Regulation of transcription The promoters of MMP-1 and MMP-13 (and most other ... polyubiquitinated (U), which targets these proteins for degradation by the proteosome Degradation of these cellular inhibitors allows translocation of NF-κB subunits to translocate to the nucleus and transactivate ... transactivate matrix metalloproteinase (MMP) promoters The IκB-like protein, Bcl-3, promotes dimerization of the 50 kDa NF-κB subunit (p50) and regulates the transcriptional activity of p50 to the transcription...
- 8
- 436
- 0
iec 60269-4-1 low-voltage fuses - supplementary requirements for fuse-links for the protection of
Ngày tải lên :
25/12/2013, 10:54
... conformity with one of its standards 6) Attention is drawn to the possibility that some of the elements of this International Standard may be the subject of patent rights The IEC shall not be held ... l’intermédiaire de: The technical content of IEC publications is kept under constant review by the IEC, thus ensuring that the content reflects current technology Information relating to this publication, ... standardization in the electrical and electronic fields To this end and in addition to other activities, the IEC publishes International Standards Their preparation is entrusted to technical committees;...
- 42
- 420
- 2
Báo cáo khoa học: Identification of the structural determinant responsible for the phosphorylation of G-protein activated potassium channel 1 by cAMP-dependent protein kinase pdf
Ngày tải lên :
07/03/2014, 00:20
... comparable to the control oocytes This indicates that the heterologously expressed GIRK1 subunit was a prominent target for PKA in vitro, after the in vivo treatment of the oocytes with a PKA inhibitor ... significant compared to control values (= no injection) This indicates that direct PKA phosphorylation of the GIRK1 protein strongly contributes to the effects of cAMP injection, but that other, ... prominent target for phosphorylation in vitro amongst the peptides tested (Fig 2B) The incorporated radioactivity relative to the amount of protein FEBS Journal 276 (2009) 6218–6226 ª 2009 The Authors...
- 9
- 403
- 0
Báo cáo khoa học: Mycobacterium tuberculosis possesses a functional enzyme for the synthesis of vitamin C, L-gulono-1,4-lactone dehydrogenase doc
Ngày tải lên :
07/03/2014, 12:20
... 5) suggests that an important portion of the fusion protein was degraded by the host proteases On the other hand, attempts to produce a His-tagged version of the The Rv1771 gene of M tuberculosis ... presence of one protein band of about 70 kDa (Fig 1, lane 2) The identity of the protein was confirmed by enterokinase treatment After digestion of the affinity-purified GSTtagged protein with enterokinase ... under these conditions, the GST-affinity eluate contained the recombinant GST fusion protein (the identified tryptic peptides are ALGPQLAQR, LGLENQGDVDPQSITGATATATH GTGVR, FQNLSAR, SDEQPKPTPGWQR, FTEM...
- 11
- 571
- 0
EUROPEAN GUIDELINES FOR THE MANAGEMENT OF CHRONIC NON-SPECIFIC LOW BACK PAIN pot
Ngày tải lên :
08/03/2014, 14:20
... ensure that the patient’s knee remains extended, with the foot in the vertical plane The affected leg is supported at the heel and the limb gently elevated The angle of leg elevation at the onset of ... sham/placebo treatments in the treatment of chronic low back pain (level D) • There is no evidence for the effectiveness of thermotherapy compared with other treatments in the treatment of chronic low ... moderate evidence that the addition of cognitive behavioural treatment to another treatment has neither short nor long term effects on functional status and behavioural outcomes (level B) • There...
- 207
- 484
- 0
Investigation of au and in as solvents for the growth of silicon nanowires on si(1 1 1)
Ngày tải lên :
16/03/2014, 15:17
... in the following the effects of different diffusion coefficients of gold and indium on silicon, the solubility of substrate atoms in the two metals, the surface tension of gold and indium and the ... HF-dip There are hints in the literature [11] that deposition of gold onto a thin layer of SiO2 on Si(1 1) favors the decomposition of SiO2, i.e that gold contributes to cleaning the surface This ... the gold distribution is the same with or without desorption step Unfortunately, no literature data about the enhancement of decomposition of a silicon oxide layer by indium were found From the...
- 6
- 565
- 0
Báo cáo Y học: Interaction of the GTS1 gene product with glyceraldehyde3-phosphate dehydrogenase 1 required for the maintenance of the metabolic oscillations of the yeast Saccharomyces cerevisiae pdf
Ngày tải lên :
31/03/2014, 21:21
... 5¢-GAAAACTGGATCCGACTTGTATGCTAAAGG-3¢ 5¢-TAATAGGAATTCTGATCATTTTGTTTTGTG-3¢ 5¢-AACAAGAATTCATGGTTAGAGTTGC-3¢ 5¢-AGGAGCTCGAGTTAAGCCTTGGCAAC-3¢ 5¢-AACTAACTAGTACTTGTATGCTAAAGG-3¢ 5¢-TTGTGTGTGTTGGTGAAATATCAAACC ... 5¢-GGAGAATTCGTTGGGCTGAGCTTCTGATCC-3¢ 5¢-TTGGGATCCTTAAGCCTTGGCAACATATTC-3¢ 5¢-CTTTGAATTCTGCTGTAACCCGTACATGCC-3¢ 5¢-ATTAGAATTCGCGGCTAAAGTTAAGCATGC-3¢ 5¢-GAAAACTGGATCCGACTTGTATGCTAAAGG-3¢ 5¢-TTGGGATCCTTAAGCCTTGGCAACATATTC-3¢ 5¢-GAAAACTGGATCCGACTTGTATGCTAAAGG-3¢ ... 5¢-TTGTGTGTGTTGGTGAAATATCAAACC AAGTTCTTGATGAATTTC-3¢ 5¢-GTGTATTTTTCTTCGTTAACACCCATGACGAA CATTGGGGCGGTG-3¢ 15 Fig Determination of the binding site of Gts1p in the 97 C-terminal residues of GAPDH3 (GAPDH3-C97) using N-terminal...
- 10
- 410
- 0